OBAGI - Tretinoin 0.05%

Prescription Only — Online Medical Assessment Required

Obagi Tretinoin 0.05% Cream is a prescription-strength retinoid formulation containing tretinoin — a clinically proven vitamin A derivative and the gold standard in topical skin renewal. Formulated at a mid-range concentration, it is suitable for users who have built tolerance to lower-strength retinoids and are ready to progress their treatment.

Tretinoin works by accelerating skin cell turnover, stimulating collagen production, and clearing blocked pores — addressing acne, fine lines, uneven texture, and pigmentation at a cellular level.

What It Treats

• Acne and recurring blemishes
• Fine lines and early signs of skin ageing
• Uneven skin tone and post-inflammatory hyperpigmentation
• Rough skin texture and dullness
• Sun-damaged skin

Prescription-Only Formula

Obagi Tretinoin 0.05% contains tretinoin, a prescription-only medicine in the UK. You’ll need to complete a free online consultation with our UK-based clinicians before purchase. This ensures the product is appropriate for your skin and that you receive the correct usage guidance.

How to Use

Apply a small, pea-sized amount to clean, dry skin in the evening. Avoid the eye area, lips, and corners of the nose. Follow with a non-comedogenic moisturiser.

Always use a broad-spectrum SPF 30+ in the morning — tretinoin increases UV sensitivity and sun protection is essential throughout treatment.

Note: An adjustment period of 4–8 weeks is normal. Mild redness, flaking, or dryness during this phase does not indicate the product is unsuitable.

Active Ingredient

• Tretinoin 0.05% (Retinoic Acid) — A potent topical retinoid that binds directly to skin cell receptors to accelerate renewal, stimulate collagen synthesis, and improve the appearance of acne, ageing, and pigmentation.

Important Safety Information

• Prescription only — always follow your prescriber’s instructions
• Not suitable during pregnancy or breastfeeding
• Mild irritation, flaking, or redness is normal during the initial adjustment phase
• Avoid use on broken, inflamed, or eczema-affected skin
• Discontinue if severe irritation develops and consult your prescriber
• Daily SPF use is essential throughout treatment

UK Delivery & Online Prescription

All tretinoin products require a free online skin consultation before dispatch. Approved orders are sent via tracked UK delivery. We are a UK-regulated supplier — your safety is our priority.

Not sure which strength is right for you? Speak to our team for guidance on tretinoin 0.025% vs 0.05% vs 0.1%, or for advice on starting a retinoid routine.

Frequently Asked Questions

What is tretinoin and how does it work?

Tretinoin is a prescription-strength retinoid — a derivative of vitamin A — that works by binding to receptors in skin cells and accelerating their natural renewal cycle. This helps clear blocked pores, reduce acne lesions, stimulate collagen production, and improve the appearance of fine lines, pigmentation, and uneven texture over time.

Why do I need a prescription for tretinoin?

Tretinoin is a prescription-only medicine in the UK. Our free online consultation connects you with UK-based clinicians who will assess your skin, confirm suitability, and provide personalised usage guidance before approving your order.

What is the difference between 0.025%, 0.05%, and 0.1% tretinoin?

0.025% is the entry-level strength, typically recommended for first-time tretinoin users or those with sensitive skin. 0.05% is a mid-range concentration suitable for users who have built tolerance to lower strengths. 0.1% is the highest available concentration, reserved for experienced users under clinical guidance. Our team can advise which strength is appropriate for your skin.

What is the difference between tretinoin cream and tretinoin gel?

Cream formulations are generally better suited to normal, dry, or sensitive skin types as they contain emollient agents that offset some of the drying effects of tretinoin. Gel formulations are typically preferred for oily or acne-prone skin as they are lighter and less occlusive. Both contain the same active ingredient at equivalent concentrations.

What is the tretinoin purge and how long does it last?

The tretinoin purge is a temporary increase in breakouts or skin flaking that can occur during the first 4–8 weeks of treatment. It happens because tretinoin accelerates cell turnover, bringing congestion to the surface more quickly. It is a normal part of the adjustment process and typically resolves as the skin acclimatises to treatment.

How long does it take to see results?

Most users begin to notice improvements in skin texture and tone within 8–12 weeks of consistent use. Significant improvements in acne, fine lines, and pigmentation are typically visible at 3–6 months. Tretinoin is a long-term treatment — consistency is key.

Can I use tretinoin if I am pregnant or breastfeeding?

No — tretinoin is not suitable for use during pregnancy or breastfeeding. If you are pregnant, planning a pregnancy, or breastfeeding, please consult your doctor for alternative options.